Gil T explains why you don’t have to worry about estrogen (E2) on testosterone replacement therapy (TRT).
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Don't don't worry about estrogen in the Least bit if you're doing everything Else correctly When Gil is talking about E2 and bone Health is he referring to free E2 you're Always referring to free we don't really I mean you have to remember that Circulating serum estradiol being an Intracrine hormone is not really that Essential like testosterone because Testosterone in men is an endocrine Hormone now the difference is that Endocrine hormones are produced by a Gland and they're secreted into the Bloodstream for systemic circulation so They act throughout your whole body even Though they're produced in one specific Area when we introduce an exogenous Testosterone into the bloodstream we are Replacing that endogenous endocrine Hormone but it's still a systemic Hormone it is not produced within cells It enters the cell from systemic Circulation with an intracrine hormone This is something that is converted Inside of the cell by the aromatase Enzyme from testosterone so the cells And within the tissues the target Tissues that utilize your estradiol are Essentially converting testosterone over And making enough estradiol for Themselves and once those receptors are Saturated any excess would then be Excreted back into the bloodstream for
Excretion via urine 85 percent of Estrogen in men is excreted via the Urine so I expect to see guys with trt With elevated serum estradi levels but Those are meaningless so don't take too Much uh stock into your estradiol levels Whether they're free or total yes shbg Does have a bind in effect estradiol not Nearly as strong as it does to androgens So don't don't worry about estrogen in The least bit if you're doing everything Else correctly consider becoming a Channel member for exclusive features Like loyalty badges Early Access to new Videos funny stuff like rough cuts and Bloopers members only photos and status Updates on the community Tab and members Only live stream chat on desktop use the Join button next to the subscribe on Mobile use the join Link in the Description